
Amifostine thiol dihydrochloride
CAS No. 14653-77-1
Amifostine thiol dihydrochloride( WR-1065 dihydrochloride | Amifostine thiol dihydrochloride )
Catalog No. M29602 CAS No. 14653-77-1
WR-1065 dihydrochloride can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of certain cancer drugs.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 42 | Get Quote |
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10MG | 67 | Get Quote |
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25MG | 111 | Get Quote |
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50MG | 164 | Get Quote |
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100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameAmifostine thiol dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionWR-1065 dihydrochloride can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of certain cancer drugs.
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DescriptionWR-1065 dihydrochloride can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of certain cancer drugs.(In Vitro):The DNA-binding activity is increased in a WR-1065 concentration-dependent manner. Cells treated with 1 mM WR-1065 dihydrochloride for 24 h revealed that all of the p53-induced genes analyzed are transactivated following WR-1065 dihydrochloride treatment, in a p53-dependent manner. Significantly, treatment with WR-1065 dihydrochloride leads to a 3-fold increase in luciferase expression driven by AP-1 and a 5-fold increase when this reporter gene is driven by NF-κB when these values are normalized to the level of the cotransfected β-galactosidase gene .(In Vivo):WR-1065 attenuates the severity of 6-OHDA-induced catalepsy when compared with 6-OHDA-lesioned rats. Also, it has been observed that WR-1065 dihydrochloride improves catalepsy in a dose-dependent manner. Pretreatment with three different doses of WR-1065 dihydrochloride (20, 40, and 80 μg/2 μL/rat) for 3 days before 6-OHDA administration, significantly elevates SOD activity and restores it to normal range compare with 6-OHDA lesioned rats .
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In Vitro——
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In Vivo——
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SynonymsWR-1065 dihydrochloride | Amifostine thiol dihydrochloride
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PathwayApoptosis
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Targetp53
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Recptorp53
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Research Area——
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Indication——
Chemical Information
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CAS Number14653-77-1
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Formula Weight207.16
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Molecular FormulaC5H16Cl2N2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 125 mg/mL (603.40 mM)
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SMILESCl.Cl.NCCCNCCS
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog



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Amifostine thiol dih...
WR-1065 dihydrochloride can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of certain cancer drugs.